Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration / G. Di Credico, J. Polesel, L. Dal Maso, F. Pauli, N. Torelli, D. Luce, L. Radoi, K. Matsuo, D. Serraino, P. Brennan, I. Holcatova, W. Ahrens, P. Lagiou, C. Canova, L. Richiardi, C.M. Healy, K. Kjaerheim, D.I. Conway, G.J. Macfarlane, P. Thomson, A. Agudo, A. Znaor, S. Franceschi, R. Herrero, T.N. Toporcov, R.A. Moyses, J. Muscat, E. Negri, M. Vilensky, L. Fernandez, M.P. Curado, A. Menezes, A.W. Daudt, R. Koifman, V. Wunsch-Filho, A.F. Olshan, J.P. Zevallos, E.M. Sturgis, G. Li, F. Levi, Z.-. Zhang, H. Morgenstern, E. Smith, P. Lazarus, C. La Vecchia, W. Garavello, C. Chen, S.M. Schwartz, T. Zheng, T.L. Vaughan, K. Kelsey, M. McClean, S. Benhamou, R.B. Hayes, M.P. Purdue, M. Gillison, S. Schantz, G.-. Yu, S.-. Chuang, P. Boffetta, M. Hashibe, A.L. Yuan-Chin, V. Edefonti. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 123:9(2020 Oct 27), pp. 1456-1463. [10.1038/s41416-020-01031-z]

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

L. Dal Maso
;
E. Negri;C. La Vecchia;V. Edefonti
Ultimo
2020-10-27

Abstract

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Settore MED/01 - Statistica Medica
24-ago-2020
Article (author)
File in questo prodotto:
File Dimensione Formato  
INHANCE_DiCredico_BJC_Merged_word.pdf

accesso aperto

Descrizione: Articolo principale con supplementary material
Tipologia: Publisher's version/PDF
Dimensione 1.41 MB
Formato Adobe PDF
1.41 MB Adobe PDF Visualizza/Apri
s41416-020-01031-z.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 1.19 MB
Formato Adobe PDF
1.19 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/784552
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 22
social impact