We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
Combined high-grade basal cell carcinoma and malignant melanoma of the skin ("malignant basomelanocytic tumor") : Report of two coses and review of the literature / J. Rodriguez, D. Nonaka, E. Kuhn, M. Reichel, J. Rosai. - In: AMERICAN JOURNAL OF DERMATOPATHOLOGY. - ISSN 0193-1091. - 27:4(2005), pp. 314-318. [10.1097/01.dad.0000171600.17692.65]
Combined high-grade basal cell carcinoma and malignant melanoma of the skin ("malignant basomelanocytic tumor") : Report of two coses and review of the literature
E. Kuhn;
2005
Abstract
We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high-grade basal cell carcinoma and malignant melanoma. Some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB-45, MART-1, Melan-A, S100-protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
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