Introduction: Metaplastic breast cancer (MBC) is a rare condition of breast tumor with different subtypes, considered a disease with worse prognosis; treatments and survival are often unclear and conflicting. Methods: We consecutively collected 153 primary MBCs of different subtypes. Breast surgery, neoadjuvant or adjuvant treatment, clinic-pathological factors, number and type of events during follow-up were considered to evaluate overall survival (OS) and invasive disease-free survival (IDFS). Results: The majority of MBC was triple-negative (TN) subtype (88.7%), G3 (95.3%), pN0 (70.6%), and with high levels of Ki-67 (93.5%). For OS and IDFS, no significant associations were seen between the different MBC subtypes. The matched triple-negative MBC (TNMBC) and ductal TNBC cohorts had similar prognosis both in terms of OS (p =.411) and IDFS (p =.981). We observed a positive trend for TNMBC patients treated in the adjuvant setting with the cyclofosfamide, methotrexate, 5-fluorouracil protocol for better OS (p =.090) and IDFS (p =.087). A poor or absent response rate was observed in the neoadjuvant setting. Conclusion: Our results demonstrate that metaplastic and ductal breast cancers with TN phenotype are similar in terms of overall and disease-free survival. Metaplastic cancers are poorly responsive to neoadjuvant treatment, and in the absence of novel targeted therapies, surgical treatment remains the first choice.
Metaplastic breast cancer: Prognostic and therapeutic considerations / G. Corso, S. Frassoni, A. Girardi, E. De Camilli, E. Montagna, M. Intra, L. Bottiglieri, A. Margherita De Scalzi, D.M. Fanianos, F. Magnoni, A. Invento, A. Toesca, F. Conforti, V. Bagnardi, G. Viale, M.A. Colleoni, P. Veronesi. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - (2020).
|Titolo:||Metaplastic breast cancer: Prognostic and therapeutic considerations|
CORSO, GIOVANNI (Primo) (Corresponding)
VERONESI, PAOLO (Ultimo)
|Parole Chiave:||breast cancer prognosis; chemotherapy treatment; metaplastic breast cancer; primary surgery; triple-negative histotype|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||2020|
|Data ahead of print / Data di stampa:||12-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jso.26248|
|Appare nelle tipologie:||01 - Articolo su periodico|