Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study / E.-. Navarrete-Munoz, J. Vioque, E. Toledo, A. Oncina-Canovas, M.A. Martinez-Gonzalez, J. Salas-Salvado, D. Corella, M. Fito, D. Romaguera, A.M. Alonso-Gomez, J. Warnberg, J.A. Martinez, L. Serra-Majem, R. Estruch, F.J. Tinahones, J. Lapetra, X. Pinto, J.A. Tur, J. Lopez-Miranda, A. Bueno-Cavanillas, P. Matia-Martin, L. Daimiel, V.M. Sanchez, J. Vidal, A.I. de Cos Blanco, E. Ros, J. Diez-Espino, N. Babio, R. Fernandez-Carrion, O. Castaner, A. Colom, L. Compan-Gabucio, I.S. Lete, E. Crespo-Oliva, I. Abete, L. Tomaino, R. Casas, J.C. Fernandez-Garcia, J.M. Santos-Lozano, I. Sarasa, J.M.A. Garcia-Rios, S. Martin-Pelaez, M. Ruiz-Canela, A. Diaz-Lopez, R. Martinez-Lacruz, M.D. Zomeno, E. Rayo, C.G. Selles, S. Canudas, A. Goday, M. Garcia-de-la-Hera. - In: EUROPEAN JOURNAL OF NUTRITION. - ISSN 1436-6207. - (2020). [Epub ahead of print] [10.1007/s00394-020-02364-4]
Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
L. Tomaino;
2020
Abstract
Purpose: We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods: A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results: We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion: This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
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