Purpose: To describe a case of unilateral multiple bullous neurosensory retina detachments (NRDs) secondary to non-Hodgkin’s aggressive large B-cell lymphoma treated with chemotherapy and high doses of systemic steroids. Methods: A case report based on patient observation, clinical records, and retinal imaging during 2 years of follow-up. Results: A 26-year-old Hispanic man presented at our clinic with sudden unilateral visual loss and multiple NRDs in the left eye with increased choroidal thickness, 1 week after oral steroid treatment due to low back pain and fever. In the following days, a non-Hodgkin’s aggressive large B-cell lymphoma was diagnosed. The patient underwent three cycles of chemotherapy (CHT) with protocol R-CHOP21 (including oral prednisone) with complete resolution of NRD. During 2 years of follow-up, no recurrence of NRD occurred, despite the need to continue CHT with oral steroids for a year due to lymphoma relapse. Conclusion: Neurosensory retina detachments may be an initial manifestation of large B-cell lymphoma as a consequence of a pro-inflammatory state involving the chorioretinal structures, thus adding steroid treatment could be useful for its resolution.

Unilateral multiple serous retinal detachments secondary to non-Hodgkin’s lymphoma responsive to systemic steroids / S. Vujosevic, C. Toma, A. Muraca, M. Alkabes, E. Villani, P. Nucci, S. De Cilla. - In: EUROPEAN JOURNAL OF OPHTHALMOLOGY. - ISSN 1120-6721. - (2020). [Epub ahead of print]

Unilateral multiple serous retinal detachments secondary to non-Hodgkin’s lymphoma responsive to systemic steroids

S. Vujosevic;M. Alkabes;E. Villani;P. Nucci;
2020

Abstract

Purpose: To describe a case of unilateral multiple bullous neurosensory retina detachments (NRDs) secondary to non-Hodgkin’s aggressive large B-cell lymphoma treated with chemotherapy and high doses of systemic steroids. Methods: A case report based on patient observation, clinical records, and retinal imaging during 2 years of follow-up. Results: A 26-year-old Hispanic man presented at our clinic with sudden unilateral visual loss and multiple NRDs in the left eye with increased choroidal thickness, 1 week after oral steroid treatment due to low back pain and fever. In the following days, a non-Hodgkin’s aggressive large B-cell lymphoma was diagnosed. The patient underwent three cycles of chemotherapy (CHT) with protocol R-CHOP21 (including oral prednisone) with complete resolution of NRD. During 2 years of follow-up, no recurrence of NRD occurred, despite the need to continue CHT with oral steroids for a year due to lymphoma relapse. Conclusion: Neurosensory retina detachments may be an initial manifestation of large B-cell lymphoma as a consequence of a pro-inflammatory state involving the chorioretinal structures, thus adding steroid treatment could be useful for its resolution.
Non-Hodgkin's lymphoma; serous retinal detachments; systemic steroids
Settore MED/30 - Malattie Apparato Visivo
2020
17-giu-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/783181
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