Background: During healthcare guideline development, panel members often have implicit, different definitions of health outcomes that can lead to misunderstandings about how important these outcomes are and how to balance benefits and harms. McMaster GRADE Centre researchers developed 'health outcome descriptors' for standardizing descriptions of health outcomes and overcoming these problems to support the European Commission Initiative on Breast Cancer (ECIBC) Guideline Development Group (GDG). We aimed to determine which aspects of the development, content, and use of health outcome descriptors were valuable to guideline developers. Methods: We developed 24 health outcome descriptors related to breast cancer screening and diagnosis for the European Commission Breast Guideline Development Group (GDG). Eighteen GDG members provided feedback in written format or in interviews. We then evaluated the process and conducted two health utility rating surveys. Results: Feedback from GDG members revealed that health outcome descriptors are probably useful for developing recommendations and improving transparency of guideline methods. Time commitment, methodology training, and need for multidisciplinary expertise throughout development were considered important determinants of the process. Comparison of the two health utility surveys showed a decrease in standard deviation in the second survey across 21 (88%) of the outcomes. Conclusions: Health outcome descriptors are feasible and should be developed prior to the outcome prioritization step in the guideline development process. Guideline developers should involve a subgroup of multidisciplinary experts in all stages of development and ensure all guideline panel members are trained in guideline methodology that includes understanding the importance of defining and understanding the outcomes of interest.
Development and use of health outcome descriptors : A guideline development case study / T. Baldeh, Z. Saz-Parkinson, P. Muti, N. Santesso, G.P. Morgano, W. Wiercioch, R. Nieuwlaat, A. Grawingholt, M. Broeders, S. Duffy, S. Hofvind, L. Nystrom, L. Ioannidou-Mouzaka, S. Warman, H. McGarrigle, S. Knox, P. Fitzpatrick, P.G. Rossi, C. Quinn, B. Borisch, A. Lebeau, C. De Wolf, M. Langendam, T. Piggott, L. Giordano, C. Van Landsveld-Verhoeven, J. Bernier, P. Rabe, H.J. Schunemann. - In: HEALTH AND QUALITY OF LIFE OUTCOMES. - ISSN 1477-7525. - 18:1(2020 Jun 05), pp. 167.1-167.21.
|Titolo:||Development and use of health outcome descriptors : A guideline development case study|
|Parole Chiave:||Guideline methodology; Health outcomes; Health states; Health utility; Evidence-Based Medicine; Health Status Indicators; Humans; Outcome Assessment, Health Care; Quality of Life; Practice Guidelines as Topic|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||5-giu-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/s12955-020-01338-8|
|Appare nelle tipologie:||01 - Articolo su periodico|