Background: Clear cell morphology has been described in several cutaneous neoplasms either as a specific feature of some entities either as a morphological variant in the spectrum, and these two entities are frequently considered together in the differential diagnosis. Methods: We reviewed our series of cases occurred in our laboratory in order to further quantify the number of cases showing morphological features of tricholemmal differentiation and to investigate other clinical or histological difference. We retrieved 91 cases and, for each of them, all the clinical data regarding age, sex, clinical features, and clinical suspicious were collected, when available. Results: The revision of the specimens concluded with a final diagnosis of tricholemmal carcinoma in 15 cases (17%), all the other cases were thus considered as squamous cell carcinoma with clear cell features. No statistically significant correlations were observed with the demografic or clinicopatholagical parameters such as age, sex or dimensions, but morphological revision highlighted a potentially greater "vertical" growth frequently not matched by a concomitant radial one in tricholemmal carcinoma than in squamous tumors. Conclusions: The debate upon the diagnostic distinction of these tumours is still ongoing with authors proposing the tricholemmal carcinoma as a variant of a squamous cell carcinoma rather than a distinct entity. Further studies are needed to confirm our data and to evaluate the reproducibility of this feature.

Cutaneous tricholemmal carcinoma: a 15-years single centre experience / F.L. Boggio, E. Guanziroli, M. Barella, L. Venegoni, E. Berti, S. Ferrero, A. Coggi, R. Gianotti, A. Del Gobbo. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 1827-1820. - (2020). [Epub ahead of print] [10.23736/S0392-0488.20.06672-9]

Cutaneous tricholemmal carcinoma: a 15-years single centre experience

F.L. Boggio
Primo
;
E. Guanziroli
Secondo
;
M. Barella;L. Venegoni;E. Berti;S. Ferrero;R. Gianotti
Penultimo
;
A. Del Gobbo
Ultimo
2020

Abstract

Background: Clear cell morphology has been described in several cutaneous neoplasms either as a specific feature of some entities either as a morphological variant in the spectrum, and these two entities are frequently considered together in the differential diagnosis. Methods: We reviewed our series of cases occurred in our laboratory in order to further quantify the number of cases showing morphological features of tricholemmal differentiation and to investigate other clinical or histological difference. We retrieved 91 cases and, for each of them, all the clinical data regarding age, sex, clinical features, and clinical suspicious were collected, when available. Results: The revision of the specimens concluded with a final diagnosis of tricholemmal carcinoma in 15 cases (17%), all the other cases were thus considered as squamous cell carcinoma with clear cell features. No statistically significant correlations were observed with the demografic or clinicopatholagical parameters such as age, sex or dimensions, but morphological revision highlighted a potentially greater "vertical" growth frequently not matched by a concomitant radial one in tricholemmal carcinoma than in squamous tumors. Conclusions: The debate upon the diagnostic distinction of these tumours is still ongoing with authors proposing the tricholemmal carcinoma as a variant of a squamous cell carcinoma rather than a distinct entity. Further studies are needed to confirm our data and to evaluate the reproducibility of this feature.
Clear cell tumors; Squamous cell carcinoma; Tricholemmal carcinoma; Appendageal tumors
Settore MED/35 - Malattie Cutanee e Veneree
16-ott-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/782481
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