Inflammation is a physiological response to injury, stimulating tissue repair and regeneration. However, the presence of peculiar individual conditions can negatively perturb the resolution phase eventually leading to a state of low-grade systemic chronic inflammation, characterized by tissue and organ damages and increased susceptibility to non-communicable disease. Marine n-3 polyunsaturated fatty acids (n-3 PUFAs), mainly eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are able to influence many aspects of this process. Experiments performed in various animal models of obesity, Alzheimer's disease and multiple sclerosis have demonstrated that n-3 PUFAs can modulate the basic mechanisms as well as the disease progression. This review describes the available data from experimental studies to the clinical trials.
Marine n-3 polyunsaturated fatty acids : Efficacy on inflammatory-based disorders / C. Parolini. - In: LIFE SCIENCES. - ISSN 0024-3205. - 263(2020 Dec 15), pp. 118591.1-118591.11.
|Titolo:||Marine n-3 polyunsaturated fatty acids : Efficacy on inflammatory-based disorders|
PAROLINI, CINZIA [Writing – Original Draft Preparation] (Corresponding)
|Parole Chiave:||Alzheimer's disease; Inflammation; Marine fish; Multiple sclerosis; Obesity; Specialized pro-resolving mediators|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||15-dic-2020|
|Data ahead of print / Data di stampa:||15-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.lfs.2020.118591|
|Appare nelle tipologie:||01 - Articolo su periodico|