Background: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery. Aim: To identify the risk factors for N+ cancer in UC patients. Methods: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N−) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses. Results: A total of 130 patients were included. Median duration of disease was 21 years (1–52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+. Conclusion: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

Risk factors for locally advanced cancer associated with ulcerative colitis : Results of a retrospective multicentric study in the era of biologics / M. Rottoli, M. Tanzanu, F. Di Candido, F. Colombo, A. Frontali, P.C. Chandrasinghe, G. Pellino, M. Frasson, J. Warusavitarne, Y. Panis, G.M. Sampietro, A. Spinelli, G. Poggioli. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 52:1(2020 Jan), pp. 33-37.

Risk factors for locally advanced cancer associated with ulcerative colitis : Results of a retrospective multicentric study in the era of biologics

M. Rottoli
;
F. Colombo;A. Frontali;
2020-01

Abstract

Background: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery. Aim: To identify the risk factors for N+ cancer in UC patients. Methods: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N−) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses. Results: A total of 130 patients were included. Median duration of disease was 21 years (1–52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+. Conclusion: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.
Cancer; Lymph nodes; Ulcerative colitis
Settore MED/18 - Chirurgia Generale
Article (author)
File in questo prodotto:
File Dimensione Formato  
Dig Liv Dis 2019 Rottoli-Colombo.pdf

accesso riservato

Descrizione: in press
Tipologia: Publisher's version/PDF
Dimensione 486.45 kB
Formato Adobe PDF
486.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
1-s2.0-S159086581930787X-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 482.04 kB
Formato Adobe PDF
482.04 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/781880
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 2
social impact