Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results:In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.

Cellulose nanocrystals : a multimodal tool to enhance the targeted drug delivery against bone disorders / L. Zoia, A. Morelli, L. Talamini, M.B. Violatto, A.B. Lovati, S. Lopa, C. Recordati, C. Toffanin, A. Salanti, L. Russo, L. Colombo, M. Moretti, M. Salmona, B.L. Ferla, P. Bigini. - In: NANOMEDICINE. - ISSN 1743-5889. - 15:23(2020 Aug), pp. 2271-2285.

Cellulose nanocrystals : a multimodal tool to enhance the targeted drug delivery against bone disorders

L. Zoia;A.B. Lovati;S. Lopa;C. Recordati;
2020-08

Abstract

Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and an anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology and in vitro uptake and toxicity assays were carried out. Results:In vivo CNC-ALN did not modify bone tropism and lung penetration, whereas its liver and kidney accumulation was slightly higher compared with CNCs alone. In vitro studies showed that CNC-ALN did not impair ALN's effect on osteoclasts, whereas CNC-DOX confirmed the therapeutic potential against bone metastatic cancer cells. Conclusions: This study provides robust proof of the potential of CNCs as easy, flexible and specific carriers to deliver compounds to the bone.
bone tropism; cellulose nanocrystals; drug-delivery system; surface functionalization
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
set-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/779526
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