Background: We studied the relationship between smoking and lung cancer risk in Harbin, Heilongjiang province, northeast China, an area with a very high baseline risk of lung cancer in both sexes, using data from a case-control study of lung cancer conducted between 1987 and 1990. Patients and methods: Cases were 218 patients with incident, histologically confirmed lung cancer and controls were 436 patients admitted to the same hospital with non-neoplastic and non-lung diseases. Results: Compared with never-smokers, the multivariate odds ratio (OR) for current smokers was 3.47 [95% confidence interval (CI) 2.31-5.20], and for ex-smokers 1.53 (95% CI 0.81-2.87). Lung cancer risk increased by 20% (95% CI 14% to 28%) for an increment of 5 years in smoking duration, and by 29% (95% CI 15% to 45%) for an increment of five cigarettes per day. The OR for smokers reporting occupational exposure to selected known or likely lung carcinogens was 7.22, compared with non-smokers without occupational exposure. Conclusions: This study further confirms that cigarette smoking is a strong determinant of lung cancer also in this high-risk area of northeast China. (copyright) 2005 European Society for Medical Oncology.
|Titolo:||Smoking and lung cancer in Harbin, northeast China|
|Parole Chiave:||China; adult; article; cancer incidence; cancer risk; case control study; cigarette smoking; controlled study; female; gender; human; lung cancer; lung carcinogenesis; major clinical study; male; occupational exposure; occupational lung disease; priority journal; tobacco; carcinogen|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||ott-2005|
|Digital Object Identifier (DOI):||10.1093/annonc/mdi312|
|Appare nelle tipologie:||01 - Articolo su periodico|