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EnglishIntroduction: We describe an outbreak of hepatitis A among men who have sex with men (MSM) which evolved in Sassari (Italy), between January 2017 and December 2018, close to a contextual of large concurrent hepatitis A outbreak reported in Europe and recently, in Italy. Methodology: HAV RNA detection and molecular characterization was performed from serum samples and/or stool by RT - PCR of VP1/2A junction region that ranges from nt. 2,873 to nt. 3,376. The phylogenetic correlation of the circulating hepatitis A strains was assessed by sequencing method according to the HAVNET protocol. Results: 10 Acute Hepatitis A virus (AHA)-positive cases, 8 of which were among men who have sex with men (MSM) were identified. All patients were tested at the time of hospitalization for the presence of anti-HIV antibodies, only two MSM resulted co-infected by HIV. No differences were observed in median age (37 years vs. 41 years, P-value = 0.14), severity or duration of hospitalization between seropositive and HIV-negative men. Phylogenetic analysis was conducted in 2 cases and revealed two distinct sequences of genotype IA linking to clusters recognized in MSM in other European countries in 2016. Conclusion: Our study reported a recent increase of notified hepatitis A cases attributable to cases in the European interconnectedness of MSM in Sassari, a small locality. Hepatitis A vaccination for MSM in Sardinia region is recommended; however, our data emphasize the need of hepatitis A screening and vaccination not only for MSM with occasional partners but also for those in monogamous relationships.
Outbreak of acute hepatitis A associated with men who have sex with men (MSM) in North Sardinia 2017-2018 / R. Bazzardi, E. Dore, M. Ciccozzi, A. Lai, M. Pisanu, S. Babudieri, I. Maida. - In: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES. - ISSN 1972-2680. - 14:9(2020 Sep 30), pp. 1065-1070.
| Titolo: | Outbreak of acute hepatitis A associated with men who have sex with men (MSM) in North Sardinia 2017-2018 |
| Autori: | |
| Parole Chiave: | AHA; MSM; hepatitis A virus; risk factors; |
| Settore Scientifico Disciplinare: | Settore MED/42 - Igiene Generale e Applicata Settore MED/17 - Malattie Infettive |
| Data di pubblicazione: | 30-set-2020 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3855/jidc.12184 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 12184-Article Text-114707-1-10-20201006.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |
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