Purpose: To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results: 228 subjects (120 males; mean age of 42.82 ± 14.73 years) were included. Most common phenotype of uveitis was posterior (n = 81; 35.53%), and panuveitis (n = 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46, p = .003), vitreous haze (OR: 2.14, p = .018), and use of immunosuppressive therapies (OR: 5.45, p = .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84; p = .02). Conclusions: Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of “cure” may be a valuable clinical endpoint in trials for OTB.
Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the “Cure” in Ocular Tuberculosis / A. Agarwal, R. Agrawal, D. Raje, I. Testi, S. Mahajan, D.V. Gunasekeran, K. Aggarwal, S.I. Murthy, M. Westcott, S.-. Chee, P. Mccluskey, S.L. Ho, S. Teoh, L. Cimino, J. Biswas, S. Narain, M. Agarwal, P. Mahendradas, M. Khairallah, N. Jones, I. Tugal-Tutkun, K. Babu, S. Basu, E. Carreno, R. Lee, H. Al-Dhibi, B. Bodaghi, A. Invernizzi, D.A. Goldstein, C.P. Herbort, T. Barisani-Asenbauer, J.J. Gonzalez-Lopez, S. Androudi, R. Bansal, B. Moharana, S.D. Esposti, A. Tasiopoulou, S. Nadarajah, M. Agarwal, S. Abraham, R. Vala, R. Singh, A. Sharma, K. Sharma, M. Zierhut, O.M. Kon, E.T. Cunningham, J.H. Kempen, Q.D. Nguyen, C. Pavesio, V. Gupta. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - (2020). [Epub ahead of print] [10.1080/09273948.2020.1761401]
Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the “Cure” in Ocular Tuberculosis
A. Invernizzi;
2020
Abstract
Purpose: To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results: 228 subjects (120 males; mean age of 42.82 ± 14.73 years) were included. Most common phenotype of uveitis was posterior (n = 81; 35.53%), and panuveitis (n = 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46, p = .003), vitreous haze (OR: 2.14, p = .018), and use of immunosuppressive therapies (OR: 5.45, p = .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84; p = .02). Conclusions: Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of “cure” may be a valuable clinical endpoint in trials for OTB.
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