The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.

Analysis of SARS-CoV-2 vertical transmission during pregnancy / C. Fenizia, M. Biasin, I. Cetin, P. Vergani, D. Mileto, A. Spinillo, M.R. Gismondo, F. Perotti, C. Callegari, A. Mancon, S. Cammarata, I. Beretta, M. Nebuloni, D.L. Trabattoni, M.S. Clerici, V.M. Savasi. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 11:1(2020 Dec), pp. 5128.1-5128.10. [10.1038/s41467-020-18933-4]

Analysis of SARS-CoV-2 vertical transmission during pregnancy

C. Fenizia
Co-primo
;
M. Biasin
Co-primo
;
I. Cetin;D. Mileto;M.R. Gismondo;A. Mancon;S. Cammarata;M. Nebuloni;D.L. Trabattoni;M.S. Clerici;V.M. Savasi
2020

Abstract

The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.
Settore MED/04 - Patologia Generale
dic-2020
12-ott-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/773579
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