Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.
The Role of Resveratrol in Mammalian Reproduction / R. Pasquariello, N. Verdile, T. Brevini, F. Gandolfi, C. Boiti, M. Zerani, M. Maranesi. - In: MOLECULES. - ISSN 1420-3049. - 25:19(2020 Oct 05).
|Titolo:||The Role of Resveratrol in Mammalian Reproduction|
PASQUARIELLO, ROLANDO (Primo)
GANDOLFI, FULVIO (Corresponding)
|Parole Chiave:||polyphenols; reproduction; phytoestrogens; ovary function; sirtuin; testis function; spermatozoa; cryopreservation; sperm quality; oocyte quality;|
|Settore Scientifico Disciplinare:||Settore VET/01 - Anatomia degli Animali Domestici|
Settore VET/02 - Fisiologia Veterinaria
|Progetto:||PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE"|
|Data di pubblicazione:||5-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/molecules25194554|
|Appare nelle tipologie:||01 - Articolo su periodico|