Background: Although studies assessing cardiovascular comorbidities and myocardial injury in Coronavirus disease 2019 (COVID-19) patients have been published, no reports focused on clinical outcomes of myocardial injury in patients with and without chronic coronary syndromes (CCS) are currently available. Methods: In this study, consecutive COVID-19 patients admitted to four different institutions were screened for enrolment. Patients were divided into two groups (CCS vs. no-CCS). Association with in-hospital mortality and related predictors represented the main study outcome; myocardial injury and its predictors were deemed secondary outcomes. Results: A total of 674 COVID-19 patients were enrolled, 112 (16.6%) with an established history of CCS. Myocardial injury occurred in 43.8% patients with CCS vs. 14.4% patients without CCS, as confirmed by high-sensitivity cardiac troponin (hs-cTn) elevation on admission or during hospitalization. The mortality rate in the CCS cohort was nearly three-fold higher. After adjusting for disease severity, myocardial injury resulted significantly associated with in-hospital mortality in the no-CCS group but not in CCS patients. Conclusions: Patients with CCS and COVID-19 showed high mortality rate. Myocardial injury may be a bystander in CCS patients and COVID-19, while in patients without known history of CCS, myocardial injury has a significant role in predicting poor outcomes.
Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease / M. Schiavone, A. Gasperetti, M. Mancone, A.V. Kaplan, C. Gobbi, G. Mascioli, M. Busana, A.M. Saguner, G. Mitacchione, A. Giacomelli, G. Sardella, M. Viecca, F. Duru, S. Antinori, S. Carugo, A.L. Bartorelli, C. Tondo, M. Galli, F. Fedele, G.B. Forleo. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 9:10(2020 Oct).
|Titolo:||Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease|
SCHIAVONE, MARCO (Primo)
GASPERETTI, ALESSIO (Secondo)
|Parole Chiave:||COVID-19; cardiac troponin; chronic coronary syndromes; coronary artery disease; myocardial injury|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/jcm9103263|
|Appare nelle tipologie:||01 - Articolo su periodico|