SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital

Giovanni, S.; Barassi, A.; Miozzo, M.R.; Laura, S.; Andrea, P.; Nicola, O.; Colosio, C.; Felisati, G.; Davi', M.; Alberto Giovanni Gerli,; Centanni, S.

doi:10.1186/s12890-020-01237-0

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Background: COVID-19 is an infectious disease caused by a novel coronavirus (SARS-CoV-2). The immunopathogenesis of the infection is currently unknown. Healthcare workers (HCWs) are at highest risk of infection and disease. Aim of the study was to assess the sero-prevalence of SARS-CoV-2 in an Italian cohort of HCWs exposed to COVID-19 patients. Methods: A point-of-care lateral flow immunoassay (BioMedomics IgM-IgG Combined Antibody Rapid Test) was adopted to assess the prevalence of IgG and IgM against SARS-CoV-2. It was ethically approved ("Milano Area 1"Ethical Committee prot. n. 2020/ST/057). Results: A total of 202 individuals (median age 45 years; 34.7% males) were retrospectively recruited in an Italian hospital (Milan, Italy). The percentage (95% CI) of recruited individuals with IgM and IgG were 14.4% (9.6-19.2%) and 7.4% (3.8-11.0%), respectively. IgM were more frequently found in males (24.3%), and in individuals aged 20-29 (25.9%) and 60-69 (30.4%) years. No relationship was found between exposure to COVID-19 patients and IgM and IgG positivity. Conclusions: The present study did show a low prevalence of SARS-CoV-2 IgM in Italian HCWs. New studies are needed to assess the prevalence of SARS-CoV-2 antibodies in HCWs exposed to COVID-19 patients, as well the role of neutralizing antibodies.

SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital / G. Sotgiu, A. Barassi, M.R. Miozzo, L. Saderi, A. Piana, N. Orfeo, C. Colosio, G. Felisati, M. Davi', A. Giovanni Gerli, S. Centanni. - In: BMC PULMONARY MEDICINE. - ISSN 1471-2466. - 20(2020 Jul 29), pp. 203.1-203.6.

Titolo:	SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospital
Autori:	Giovanni Sotgiu (Primo) [Formal Analysis] (Corresponding) BARASSI, ALESSANDRA (Secondo) [Methodology] MIOZZO, MONICA ROSA [Writing – Original Draft Preparation] Laura Saderi [Validation] Andrea Piana [Data Curation] Nicola Orfeo [Conceptualization] COLOSIO, CLAUDIO [Validation] FELISATI, GIOVANNI [Membro del Collaboration Group] DAVI', MATTEO [Data Curation] Alberto Giovanni Gerli (Penultimo) [Conceptualization] CENTANNI, STEFANO (Ultimo) [Writing – Review & Editing] mostra contributor esterni nascondi contributor esterni
Parole Chiave:	seroprevalence; COVID-19; SARS-CoV-2; IG; HCWs
Settore Scientifico Disciplinare:	Settore MED/01 - Statistica Medica Settore MED/10 - Malattie dell'Apparato Respiratorio
Data di pubblicazione:	29-lug-2020
Rivista:	BMC PULMONARY MEDICINE
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1186/s12890-020-01237-0
Appare nelle tipologie:	01 - Articolo su periodico

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/2434/772034

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