Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and critically determines cellular oxygen availability. Although high Hb-O2 affinity can cause tissue hypoxia under conditions of well O2 saturated blood, individual differences in p50 are commonly not considered in clinical routine. Here, we investigated the diversity in Hb-O2 affinity in the context of physiological relevance. Oxyhaemoglobin dissociation curves (ODCs) of 60 volunteers (18-40 years, both sexes, either endurance trained or untrained) were measured at rest and after maximum exercise (VO2max) test. At rest, p50 values of all participants ranged over 7 mmHg. For comparison, right shift of ODC after VO2max test, representing the maximal physiological range to release oxygen to the tissue, indicated a p50 difference of up to 10 mmHg. P50 at rest differs significantly between women and men, with women showing lower Hb-O2 affinity that is determined by higher 2,3-BPG and BPGM levels. Regular endurance exercise did not alter baseline Hb-O2 affinity. Thus, p50 diversity is already high at baseline level and needs to be considered under conditions of impaired tissue oxygenation. For fast prediction of Hb-O2 affinity by blood gas analysis, only venous but not capillary blood samples can be recommended.
A broad diversity in oxygen affinity to haemoglobin / B. Balcerek, M. Steinach, J. Lichti, M.A. Maggioni, P.N. Becker, R. Labes, H. Gunga, P.B. Persson, M. Fähling. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 10:1(2020 Dec 01).
|Titolo:||A broad diversity in oxygen affinity to haemoglobin|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
|Data di pubblicazione:||1-dic-2020|
|Data ahead of print / Data di stampa:||9-ott-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/s41598-020-73560-9|
|Appare nelle tipologie:||01 - Articolo su periodico|