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EnglishBackground and objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy were assessed in 526 house dust mite (HDM)-allergic patients submitted to the detection of IgE to Der p 10 and 100 atopic controls not sensitized to HDM. Results. Shrimp allergy occurred in 9% of patients (vs 0% of 100 atopic controls not sensitized to HDM; p < 0.001). Shrimp-allergic patients were less frequently hypersensitive to airborne allergens other than HDM than crustacean-tolerant subjects (35% vs 58.8%; p < 0.005). Only 51% of tropomyosin-sensitized patients had shrimp allergy, and these showed significantly higher Der p 10 IgE levels than shrimp-tolerant ones (mean 22.2 KU/l vs 6.2 KU/l; p < 0.05). Altogether 53% of shrimp-allergic patients did not react against tropomyosin. Conclusions. Shrimp allergy seems to occur uniquely in association with hypersensitivity to HDM allergens and tropomyosin is the main shrimp allergen but not a major one, at least in Italy. Along with tropomyosin-specific IgE levels, monosensitization to HDM seems to represent a risk factor for the development of shrimp allergy among HDM allergic patients.
House dust mite allergy and shrimp allergy: a complex interaction / G. Celi, I. Brusca, E. Scala, D. Villalta, E. Pastorello, L. Farioli, G. Cortellini, G. Deleonardi, P. Galati, L. Losappio, G. Manzotti, B. Pirovano, L. Muratore, F.M. F Cucinelli, A. Musarra, M. Cilia, E.N. A Aruanno, F. Ria, M. F Patria, E. Varin, B. R Polillo, V. Sargentini, O. Quercia, C. G Uasuf, S. Zampogna, M. Carollo, S. Graci, R. Asero. - In: EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY. - ISSN 1764-1489. - 52:5(2020 Sep 01), pp. 205-209.
| Titolo: | House dust mite allergy and shrimp allergy: a complex interaction. |
| Autori: | |
| Parole Chiave: | food allergy; peach allergy; lipid transfer protein; SPT; diagnosis; |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna |
| Data di pubblicazione: | 1-set-2020 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.23822/EurAnnACI.1764-1489.108. |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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