Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor nerve terminals and blocks the release of acetylcholine via the specific cleavage of the synaptosomal-associated protein of 25-kDa. Localized injections of BoNT/A are widely employed in clinical neurology to treat several human diseases characterized by muscle hyperactivity. It is generally assumed that the effects of BoNT/A remain localized to the injection site. However, several neurophysiological studies have provided evidence for central effects of BoNT/A, raising the issue of how these actions arise. Here we review these data and discuss the possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits. © 2009 International Society for Neurochemistry.
A reappraisal of the central effects of botulinum neurotoxin type A : by what mechanism? / M. Caleo, F. Antonucci, L. Restani, R. Mazzocchio. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 109:1(2009 Apr), pp. 15-24.
|Titolo:||A reappraisal of the central effects of botulinum neurotoxin type A : by what mechanism?|
|Parole Chiave:||Botulinum neurotoxins; Movement disorders; Neuromuscular junction; Retrograde axonal transport; Synaptic transmission; Synaptosomal-associated protein of 25-kDa; Animals; Axonal Transport; Botulinum Toxins, Type A; Catalysis; Central Nervous System; Humans; Injections, Intramuscular; Neuromuscular Diseases; Synapses|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||apr-2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1471-4159.2009.05887.x|
|Appare nelle tipologie:||01 - Articolo su periodico|