Purpose: To report real-world diagnostic performance of chest x-ray (CXR) readings during the COVID-19 pandemic. Methods: In this retrospective observational study we enrolled all patients presenting to the emergency department of a Milan-based university hospital from February 24th to April 8th 2020 who underwent nasopharyngeal swab for reverse transcriptase-polymerase chain reaction (RT-PCR) and anteroposterior bedside CXR within 12 h. A composite reference standard combining RT-PCR results with phone-call-based anamnesis was obtained. Radiologists were grouped by CXR reading experience (Group-1, >10 years; Group-2, <10 years), diagnostic performance indexes were calculated for each radiologist and for the two groups. Results: Group-1 read 435 CXRs (77.0 % disease prevalence): sensitivity was 89.0 %, specificity 66.0 %, accuracy 83.7 %. Group-2 read 100 CXRs (73.0 % prevalence): sensitivity was 89.0 %, specificity 40.7 %, accuracy 76.0 %. During the first half of the outbreak (195 CXRs, 66.7 % disease prevalence), overall sensitivity was 80.8 %, specificity 67.7 %, accuracy 76.4 %, Group-1 sensitivity being similar to Group-2 (80.6 % versus 81.5 %, respectively) but higher specificity (74.0 % versus 46.7 %) and accuracy (78.4 % versus 69.0 %). During the second half (340 CXRs, 81.8 % prevalence), overall sensitivity increased to 92.8 %, specificity dropped to 53.2 %, accuracy increased to 85.6 %, this pattern mirrored in both groups, with decreased specificity (Group-1, 58.0 %; Group-2, 33.3 %) but increased sensitivity (92.7 % and 93.5 %) and accuracy (86.5 % and 81.0 %, respectively). Conclusions: Real-world CXR diagnostic performance during the COVID-19 pandemic showed overall high sensitivity with higher specificity for more experienced radiologists. The increase in accuracy over time strengthens CXR role as a first line examination in suspected COVID-19 patients.
Chest x-ray in the COVID-19 pandemic: Radiologists’ real-world reader performance / A. Cozzi, S. Schiaffino, F. Arpaia, G. Della Pepa, S. Tritella, P. Bertolotti, L. Menicagli, C.G. Monaco, L.A. Carbonaro, R. Spairani, B. Babaei Paskeh, F. Sardanelli. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - 132(2020 Nov).
|Titolo:||Chest x-ray in the COVID-19 pandemic: Radiologists’ real-world reader performance|
COZZI, ANDREA (Primo)
SARDANELLI, FRANCESCO (Ultimo)
|Parole Chiave:||COVID-19; Pneumonia, viral; Radiography, thoracic; Severe acute respiratory syndrome coronavirus 2|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
Settore MED/17 - Malattie Infettive
|Data di pubblicazione:||nov-2020|
|Data ahead of print / Data di stampa:||10-set-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejrad.2020.109272|
|Appare nelle tipologie:||01 - Articolo su periodico|