Objectives: To describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019. Design: Analysis of patients in the Coracle registry from February 22, 2020, to April 1, 2020. Setting: Hospitals in the Piedmont, Lombardy, Tuscany, and Lazio regions of Italy. Patients: Nine-hundred forty-eight patients hospitalized for coronavirus disease 2019. Interventions: None. Measurements and Main Results: Among 948 patients, 122 (12.87%) received invasive ventilation, 637 (67.19%) received supplemental oxygen only, and 189 (19.94%) received no respiratory support. The median (quartile 1–quartile 3) age was 65 years (54–76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. There were 606 men (63.9%) in this study, and they were more likely to receive respiratory support than women (p < 0.0001). The rate of in-hospital death for invasive ventilation recipients was 22.95%, 12.87% for supplemental oxygen recipients, and 7.41% for those who received neither (p = 0.0004). A sensitivity analysis of the 770 patients less than 80 years old revealed a lower, but similar mortality trend (18.02%, 8.10%, 5.23%; p = 0.0008) among the 14.42%, 65.71%, and 19.87% of patients treated with mechanical ventilation, supplemental oxygen only, or neither. Overall, invasive ventilation recipients who died were significantly older than those who survived (median age: 68.5 yr [60–81.36 yr] vs 62.5 yr [55.52–71 yr]; p = 0.0145). Conclusions: Among patients hospitalized for coronavirus disease 2019, 13% received mechanical ventilation, which was associated with a mortality rate of 23%.

Inpatient Mortality According to Level of Respiratory Support Received for Severe Acute Respiratory Syndrome Coronavirus 2 (Coronavirus Disease 2019) Infection: A Prospective Multicenter Study / A. Palazzuoli, F. Ruberto, G.M. De Ferrari, G. Forleo, G.G. Secco, G.M. Ruocco, F. D'Ascenzo, F. Mojoli, S. Monticone, A. Paggi, M. Vicenzi, S. Corcione, A.G. Palazzo, M. Landolina, E. Taravelli, G. Tavazzi, F. Blasi, M. Mancone, L.I. Birtolo, F. Alessandri, F. Infusino, F. Pugliese, F. Fedele, F.G. De Rosa, M. Emmett, J.M. Schussler, P.A. McCullough, K.M. Tecson. - In: CRITICAL CARE EXPLORATIONS. - ISSN 2639-8028. - 2:9(2020 Sep 18). [10.1097/CCE.0000000000000220]

Inpatient Mortality According to Level of Respiratory Support Received for Severe Acute Respiratory Syndrome Coronavirus 2 (Coronavirus Disease 2019) Infection: A Prospective Multicenter Study

Vicenzi, Marco;Blasi, Francesco;
2020-09-18

Abstract

Objectives: To describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019. Design: Analysis of patients in the Coracle registry from February 22, 2020, to April 1, 2020. Setting: Hospitals in the Piedmont, Lombardy, Tuscany, and Lazio regions of Italy. Patients: Nine-hundred forty-eight patients hospitalized for coronavirus disease 2019. Interventions: None. Measurements and Main Results: Among 948 patients, 122 (12.87%) received invasive ventilation, 637 (67.19%) received supplemental oxygen only, and 189 (19.94%) received no respiratory support. The median (quartile 1–quartile 3) age was 65 years (54–76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. There were 606 men (63.9%) in this study, and they were more likely to receive respiratory support than women (p < 0.0001). The rate of in-hospital death for invasive ventilation recipients was 22.95%, 12.87% for supplemental oxygen recipients, and 7.41% for those who received neither (p = 0.0004). A sensitivity analysis of the 770 patients less than 80 years old revealed a lower, but similar mortality trend (18.02%, 8.10%, 5.23%; p = 0.0008) among the 14.42%, 65.71%, and 19.87% of patients treated with mechanical ventilation, supplemental oxygen only, or neither. Overall, invasive ventilation recipients who died were significantly older than those who survived (median age: 68.5 yr [60–81.36 yr] vs 62.5 yr [55.52–71 yr]; p = 0.0145). Conclusions: Among patients hospitalized for coronavirus disease 2019, 13% received mechanical ventilation, which was associated with a mortality rate of 23%.
coronavirus disease 2019; inpatient mortality; invasive ventilation; respiratory support; severe acute respiratory syndrome coronavirus 2; supplemental oxygen
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/768144
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