The discovery of opioid receptor expression on immune cells has originated a large research activity on the possible modulation by opioid drugs of immune system responses. In this chapter we describe an easy methodology useful to obtain information about the potential immunomodulatory activity of opioid drugs. An in vivo treatment schedule is used, and macrophages are studied for their ability to release different cytokines.

Evaluation of Murine Macrophage Cytokine Production After In Vivo Morphine Treatment / S. Franchi, M. Castelli, S. Moretti, A.E. Panerai, P.G. Sacerdote (METHODS IN MOLECULAR BIOLOGY). - In: Opioid Receptors : Methods and Protocols / [a cura di] S.M. Spampinato. - [s.l] : Springer, 2021. - ISBN 9781071608838. - pp. 199-207 [10.1007/978-1-0716-0884-5_18]

Evaluation of Murine Macrophage Cytokine Production After In Vivo Morphine Treatment

S. Franchi;M. Castelli;A.E. Panerai;P.G. Sacerdote
2021

Abstract

The discovery of opioid receptor expression on immune cells has originated a large research activity on the possible modulation by opioid drugs of immune system responses. In this chapter we describe an easy methodology useful to obtain information about the potential immunomodulatory activity of opioid drugs. An in vivo treatment schedule is used, and macrophages are studied for their ability to release different cytokines.
Cytokines; Lipopolysaccharide; Murine macrophages; Morphine; Opioid-induced immunosuppression
Settore BIO/14 - Farmacologia
2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/767705
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