Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.

Headaches and Magnesium : Mechanisms, Bioavailability, Therapeutic Ecacy and Potential Advantage of Magnesium Pidolate / J.A.M. Maier, G. Pickering, E. Giacomoni, A. Cazzaniga, P. Pellegrino. - In: NUTRIENTS. - ISSN 2072-6643. - 12:9(2020 Aug 31), pp. 2660.1-2660.14. [10.3390/nu12092660]

Headaches and Magnesium : Mechanisms, Bioavailability, Therapeutic Ecacy and Potential Advantage of Magnesium Pidolate

J.A.M. Maier
Primo
;
A. Cazzaniga
Penultimo
;
P. Pellegrino
Ultimo
2020

Abstract

Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.
BBB; deficiency; headache; magnesium; migraine; pidolate.
Settore MED/04 - Patologia Generale
31-ago-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/767100
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