Background Little is known about the post-acute effects of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression. The present study focused on the 6-month follow-up of a sample of patients with major depression, after the completion of an acute 4 weeks rTMS trial, with the aim of evaluating response (in terms of sustained and late response) and relapse rates. Methods Following the completion of an acute trial of rTMS (T0-T4), 31 drug-resistant depressed patients (bipolar or unipolar) entered a naturalistic follow-up period of 6 months, with three timepoints (T5, T6, and T7) during which they were assessed with the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Results Results showed that in the 6 months following an acute transcranial magnetic stimulation (TMS) trial, a higher rate of late responders was observed among previously acute TMS nonresponders (63.64%, 7 out of 11) compared to the rate of relapse among those who had acutely responded to TMS (10%, 2 out of 20). In addition, an overall high rate of maintained response (90%) was observed. Conclusion Present findings seem to support the possibility of obtaining a clinical response also after the end of an acute TMS trial in patients with major depression. The concomitant low rate of relapse observed at the end of follow-up along with a high rate of maintained response provides further support to the post-acute efficacy of TMS. Nonetheless, further controlled studies, with larger samples and longer follow-up observation, are needed to confirm the reported results.

A 6 month follow up study on response and relapse rates following an acute trial of repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depression / C. Arici, B. Benatti, R. Cafaro, L. Cremaschi, L. Degoni, S. Pozzoli, L. Oldani, L. Molteni, F. Giorgetti, A. Priori, C. Viganò, B. Dell'Osso. - In: CNS SPECTRUMS. - ISSN 1092-8529. - 27:1(2022 Feb 04), pp. PII S1092852920001807.93-PII S1092852920001807.98. [10.1017/S1092852920001807]

A 6 month follow up study on response and relapse rates following an acute trial of repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depression

C. Arici
Primo
;
B. Benatti
Secondo
;
R. Cafaro;L. Cremaschi;S. Pozzoli;L. Oldani;F. Giorgetti;A. Priori;C. Viganò
Penultimo
;
B. Dell'Osso
Ultimo
2022

Abstract

Background Little is known about the post-acute effects of repetitive transcranial magnetic stimulation (rTMS) in patients with major depression. The present study focused on the 6-month follow-up of a sample of patients with major depression, after the completion of an acute 4 weeks rTMS trial, with the aim of evaluating response (in terms of sustained and late response) and relapse rates. Methods Following the completion of an acute trial of rTMS (T0-T4), 31 drug-resistant depressed patients (bipolar or unipolar) entered a naturalistic follow-up period of 6 months, with three timepoints (T5, T6, and T7) during which they were assessed with the Hamilton Depression Rating Scale and the Young Mania Rating Scale. Results Results showed that in the 6 months following an acute transcranial magnetic stimulation (TMS) trial, a higher rate of late responders was observed among previously acute TMS nonresponders (63.64%, 7 out of 11) compared to the rate of relapse among those who had acutely responded to TMS (10%, 2 out of 20). In addition, an overall high rate of maintained response (90%) was observed. Conclusion Present findings seem to support the possibility of obtaining a clinical response also after the end of an acute TMS trial in patients with major depression. The concomitant low rate of relapse observed at the end of follow-up along with a high rate of maintained response provides further support to the post-acute efficacy of TMS. Nonetheless, further controlled studies, with larger samples and longer follow-up observation, are needed to confirm the reported results.
follow-up; late response; Major depression; relapse; repetitive TMS (rTMS);
Settore MED/25 - Psichiatria
Settore MED/26 - Neurologia
4-set-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/766635
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