Background: The lack of specific vaccines or drugs against coronavirus disease 2019 (COVID-19) warrants studies focusing on alternative clinical approaches to reduce the spread of this pandemic disease. In this study, we investigated whether anti-influenza vaccination plays a role in minimizing the diffusion of COVID-19 in the Italian population aged 65 and over. Methods: Four COVID-19 outcomes were used: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence, hospitalizations for COVID-19 symptoms, admissions to intensive care units for reasons related to SARS-CoV-2, and deaths attributable to COVID-19. Results: At univariate analyses, the influenza vaccination coverage rates correlated negatively with all COVID-19 outcomes (Beta ranging from −134 to −0.61; all p < 0.01). At multivariable analyses, influenza vaccination coverage rates correlated independently with SARS-CoV-2 seroprevalence (Beta (95% C.I.): −130 (−198, −62); p = 0.001), hospitalizations for COVID-19 symptoms (Beta (95% C.I.): −4.16 (−6.27, −2.05); p = 0.001), admission to intensive care units for reasons related to SARS-CoV-2 (Beta (95% C.I.): −0.58 (−1.05, −0.12); p = 0.017), and number of deaths attributable to COVID-19 (Beta (95% C.I.): −3.29 (−5.66, −0.93); p = 0.010). The R2 observed in the unadjusted analysis increased from 82% to 159% for all the considered outcomes after multivariable analyses. Conclusions: In the Italian population, the coverage rate of the influenza vaccination in people aged 65 and over is associated with a reduced spread and a less severe clinical expression of COVID-19. This finding warrants ad hoc studies to investigate the role of influenza vaccination in preventing the spread of COVID-19.
Relationship between influenza vaccination coverage rate and COVID-19 outbreak: An italian ecological study / M. Amato, J.P. Werba, B. Frigerio, D. Coggi, D. Sansaro, A. Ravani, P. Ferrante, F. Veglia, E. Tremoli, D. Baldassarre. - In: VACCINES. - ISSN 2076-393X. - 8:3(2020 Sep 20), pp. 535.1-535.11.
|Titolo:||Relationship between influenza vaccination coverage rate and COVID-19 outbreak: An italian ecological study|
COGGI, DANIELA [Membro del Collaboration Group]
VEGLIA, FABRIZIO [Formal Analysis]
TREMOLI, ELENA (Penultimo) [Membro del Collaboration Group]
BALDASSARRE, DAMIANO (Ultimo) [Supervision] (Corresponding)
|Parole Chiave:||Coronavirus spread; COVID-19; Influenza vaccination coverage rate|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||20-set-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/vaccines8030535|
|Appare nelle tipologie:||01 - Articolo su periodico|