Recent data suggest that IL-1-like molecules have been conserved during evolution. The signal transduction mechanism of IL-1 is not known, but kinase activation has been reported. With the aim of studying if human IL-1 has any effect on the leech nervous system, we have added this cytokine to segmental ganglia labeled with [32P]ortophosphoric acid; proteins have been separated by electrophoresis and phosphoproteins detected by autoradiography. In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin.
|Titolo:||Interleukin-1 and interleukin-6 modify protein phosphorylation in the central nervous system of Hirudo medicinalis|
|Autori interni:||BOTTAI, DANIELE (Primo)|
|Parole Chiave:||interleukin-1 ; interleukin-6 ; Learning ; leech ; protein phosphorylation ; serotonin|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1994|
|Digital Object Identifier (DOI):||10.1016/0006-8993(94)91830-9|
|Appare nelle tipologie:||01 - Articolo su periodico|