Background/Aim: The role of anti-PD1/PD-L1 therapy (IO) in NSCLC harboring driver mutations is questionable. This study aimed to examine the efficacy of IO in patients with non-small cell lung cancer (NSCLC) with a KRAS mutation (KRAS+). Patients and Methods: We retrospectively identified NSCLC patients harboring KRAS mutation treated with IO in our Institution. We analyzed the results in comparison to non-KRAS patients. Results: Among 328 consecutive KRAS+ NSCLC patients, 43 (13.1%) received IO in our Institution. In parallel 117 non-KRAS NSCLC patients treated with IO were selected for comparison. The baseline characteristics were similar between the two groups. No significant difference was observed between KRAS+ and non-KRAS patients in terms of mPFS (4.6 vs. 3.3 months, p=0.58) or OS (8.1 vs. 13.0 months, p=0.38). Conclusion: KRAS mutations seem to be irrelevant for selecting patients for IO that could be therefore considered an effective therapy for NSCLC patients, independently of KRAS status.
Efficacy of Anti-PD1/PD-L1 Therapy (IO) in KRAS Mutant Non-small Cell Lung Cancer Patients : a retrospective analysis / L. Gianoncelli, G. Spitaleri, A. Passaro, D. Radice, C. Fumagalli, E.D.E.L. Signore, V. Stati, C.M. Catania, E. Guerini-Rocco, M. Barberis, F.D.E. Marinis. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 40:1(2020 Jan), pp. 427-433.
|Titolo:||Efficacy of Anti-PD1/PD-L1 Therapy (IO) in KRAS Mutant Non-small Cell Lung Cancer Patients : a retrospective analysis|
|Parole Chiave:||Anti-PDI/PD-L1 therapy; Immunotherapy; KRAS; NSCLC; Aged; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutation; Programmed Cell Death 1 Receptor; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Survival Analysis; Treatment Outcome|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||gen-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.21873/anticanres.13970|
|Appare nelle tipologie:||01 - Articolo su periodico|