OBJECTIVES: To present a single-centre experience on CT pulmonary angiography (CTPA) for the assessment of hospitalised COVID-19 patients with moderate-to-high risk of pulmonary thromboembolism (PTE). METHODS: We analysed consecutive COVID-19 patients (RT-PCR confirmed) undergoing CTPA in March 2020 for PTE clinical suspicion. Clinical data were retrieved. Two experienced radiologists reviewed CTPAs to assess pulmonary parenchyma and vascular findings. RESULTS: Among 34 patients who underwent CTPA, 26 had PTE (76%, 20 males, median age 61 years, interquartile range 54-70), 20/26 (77%) with comorbidities (mainly hypertension, 44%), and 8 (31%) subsequently dying. Eight PTE patients were under thromboprophylaxis with low-molecular-weight heparin, four PTE patients had lower-limbs deep vein thrombosis at ultrasound examination (performed in 33/34 patients). Bilateral PTE characterised 19/26 cases, with main branches involved in 10/26 cases. Twelve patients had a parenchymal involvement >75%, the predominant pneumonia pattern being consolidation in 10/26 patients, ground glass opacities in 9/26, crazy paving in 5/26, and both ground glass opacities and consolidation in 2/26. CONCLUSION: COVID-19 patients are prone to PTE. ADVANCES IN KNOWLEDGE: PTE, potentially attributable to an underlying thrombophilic status, may be more frequent than expected in COVID-19 patients. Extension of prophylaxis and adaptation of diagnostic criteria should be considered.
Pulmonary thromboembolism in hospitalised COVID-19 patients at moderate to high risk by Wells score: a report from Lombardy, Italy / L. Monfardini, M. Morassi, P. Botti, R. Stellini, L. Bettari, S. Pezzotti, M. Ali, C.G. Monaco, V. Magni, A. Cozzi, S. Schiaffino, C. Bna. - In: BRITISH JOURNAL OF RADIOLOGY. - ISSN 0007-1285. - 93:1113(2020 Sep 01), p. 20200407.
|Titolo:||Pulmonary thromboembolism in hospitalised COVID-19 patients at moderate to high risk by Wells score: a report from Lombardy, Italy|
|Parole Chiave:||Aged; Comorbidity; Computed Tomography Angiography; Coronavirus Infections; Female; Hospitalization; Humans; Inpatients; Italy; Lung; Male; Middle Aged; Pandemics; Pneumonia, Viral; Pulmonary Embolism; Retrospective Studies; Risk; Betacoronavirus|
|Settore Scientifico Disciplinare:||Settore MED/36 - Diagnostica per Immagini e Radioterapia|
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Settore MED/17 - Malattie Infettive
|Data di pubblicazione:||1-set-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1259/bjr.20200407|
|Appare nelle tipologie:||01 - Articolo su periodico|