Recent studies on cull cows have shown that ovarian abnormalities, particularly ovarian insufficiency, are the main cause of reproductive failure. The aim of this study was to treat bovine ovarian failure with intraovarian administration of autologous platelet rich plasma (PRP), which is rich in growth factors, chemokines, and cytokines that could stimulate follicular growth and steroidogenesis. Twelve cows with ovarian hypofunction were enrolled in the study and they were randomly allocated in control group (CTR) and treated group (six animal for group). In the treated group, only five animals received the PRP treatment because intraovarian administration was hindered in one by a rectovaginal fistula. Animals of control group were treated by intraovarian administration of physiological solution. In the 4 weeks after PRP injection, a mild to strong increase in progesterone (PRG) concentrations was detected in four of the five cows treated. Artificial insemination (AI) resulted in four pregnancies that are still ongoing (7th month). Intraovarian administration of PRP improved ovarian function after 2 months of treatment. This effect may be due to reduction of follicular atresia or to revitalization of dormant oocytes allowing restoration of fertility.
Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction / F. Cremonesi, S. Bonfanti, A. Idda, A. Lange Consiglio. - In: FRONTIERS IN VETERINARY SCIENCE. - ISSN 2297-1769. - 7(2020 Aug), pp. 517.1-517.7.
|Titolo:||Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction|
LANGE CONSIGLIO, ANNA (Corresponding)
|Parole Chiave:||bovine; growth factors; ovarian hypofunction; platelet rich plasma; progesterone|
|Settore Scientifico Disciplinare:||Settore VET/10 - Clinica Ostetrica e Ginecologia Veterinaria|
|Data di pubblicazione:||ago-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fvets.2020.00517|
|Appare nelle tipologie:||01 - Articolo su periodico|