Highly strained unsaturated carbocyclic rings are high-energy compounds which are attracting increasing interest – not just for their peculiar structural and reactivity features – but also as modern chemical tools for bioorthogonal and in vivo chemistry, especially via inverse-electron demand Diels–Alder (iEDDA) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. This mini-review covers two main classes of compounds: 3 to 10 membered-ring cycloalkynes and trans-cycloalkenes, including some examples of cyclic enynes, dienes and bridgehead alkenes. Their molecular properties, synthesis and reactivity are presented and discussed, with an emphasis on their functionalization and reactivity.
Highly strained unsaturated carbocycles / M. Zanda, R. Bucci, N.L. Sloan, L. Topping. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2020:33(2020 Sep 07), pp. 5278-5291.
|Titolo:||Highly strained unsaturated carbocycles|
BUCCI, RAFFAELLA (Co-primo)
|Parole Chiave:||bioorthogonal chemistry; cycloaddition; cycloalkenes; cycloalkynes; strained carbocycles|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||7-set-2020|
|Data ahead of print / Data di stampa:||8-giu-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/ejoc.202000512|
|Appare nelle tipologie:||01 - Articolo su periodico|