Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.
Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations / S. Salmoiraghi, R. Cavagna, M.L.G. Montalvo, G. Ubiali, M. Tosi, B. Peruta, T. Intermesoli, E. Oldani, A. Salvi, C. Pavoni, U. Giussani, R. Bassan, A. Rambaldi, O. Spinelli. - In: GENES. - ISSN 2073-4425. - 11:9(2020), pp. 960.1-960.6.
Immature immunoglobulin gene rearrangements are recurrent in B precursor adult acute lymphoblastic leukemia carrying TP53 molecular alterations
R. Cavagna;A. Rambaldi;
2020
Abstract
Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.File | Dimensione | Formato | |
---|---|---|---|
genes-11-00960.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
209 kB
Formato
Adobe PDF
|
209 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.