The present study aims to evaluate whether influenza and pneumococcal vaccinations are associated with positive nasopharyngeal swab (NPS) testing to detect SARS-CoV-2. Data from the Italian cross-sectional web-based survey (EPICOVID19), based on a self-selection sample of individuals aged ≥18, were considered. The probability of a positive SARS-CoV-2 NPS test result as a function of influenza or anti-pneumococcal vaccination was evaluated using multivariable logistic regression, stratifying analysis by age (<65 years, ≥65 years). From April 2020, 170,731 individuals aged <65 years and 28,097 ≥65 years filled out the EPICOVID19 questionnaire. Influenza and anti-pneumococcal vaccinations were received, respectively, by 16% and 2% of those <65 years, and by 53% and 13% of those ≥65 years. SARS-CoV-2 NPS testing was reported by 6680 participants. Anti-pneumococcal and influenza vaccinations were associated with a decreased probability of a SARS-CoV-2 NPS positive test in the younger participants (OR = 0.61, 95% CI 0.41–0.91; OR = 0.85, 95%CI 0.74–0.98; respectively). A significantly lower probability of a positive test result was detected in the individuals ≥65 years who received anti-pneumococcal vaccination (OR = 0.56, 95%CI 0.33–0.95). These results need to be confirmed by further investigations, but they are relevant given the probable coexistence of influenza, bacterial infections, and COVID-19 over the coming autumn–winter season.
The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection : Data from the EPICOVID19 Web-Based Survey / M. Noale, C. Trevisan, S. Maggi, R. Antonelli Incalzi, C. Pedone, M. Di Bari, F. Adorni, N. Jesuthasan, A. Sojic, M. Galli, A. Giacomelli, S. Molinaro, F. Bianchi, C. Mastroianni, F. Prinelli. - In: VACCINES. - ISSN 2076-393X. - 8:3(2020 Aug 23), pp. 471.1-471.12.
|Titolo:||The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection : Data from the EPICOVID19 Web-Based Survey|
|Parole Chiave:||SARS-CoV-2; COVID 19; web-based survey; nasopharyngeal swab testing; influenza vaccination; pneumococcal vaccination|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||23-ago-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/vaccines8030471|
|Appare nelle tipologie:||01 - Articolo su periodico|