Developing biomarkers for psychiatric disorders represents a major challenge. Indeed, the identification of dependable brain-based measures, such as those derived from electrophysiological techniques, would represent a key step toward better profiling of patients with major psychiatric disorders. A principled neurophysiological approach would also deepen our understanding of the physiopathology and inform therapeutic decisions. The present chapter focuses on a neurophysiological technique, based on the combination of neuronavigated Transcranial Magnetic Stimulation and Electroencephalography (TMS-EEG), which allows probing directly and non-invasively cortical excitability, plasticity as well as the fundamental oscillatory properties of thalamocortical circuits. Since these parameters are often altered in psychiatric disorders, neuronavigated TMS-EEG may be in a suitable position to provide neurophysiological objective measures to support the diagnosis of psychiatric disorders, to highlight their physiopathological underpinnings, and to objectively assess the efficacy of treatment options.

Cortical Excitability, Plasticity and Oscillations in Major Psychiatric Disorders: A Neuronavigated TMS-EEG Based Approach / M. Rosanova, S. Sarasso, M. Massimini, S. Casarotto - In: Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences / [a cura di] B. Dell'Osso, G. Di Lorenzo. - [s.l] : Springer, 2020. - ISBN 9783030433550. - pp. 209-222 [10.1007/978-3-030-43356-7_15]

Cortical Excitability, Plasticity and Oscillations in Major Psychiatric Disorders: A Neuronavigated TMS-EEG Based Approach

M. Rosanova
;
S. Sarasso;M. Massimini;S. Casarotto
2020

Abstract

Developing biomarkers for psychiatric disorders represents a major challenge. Indeed, the identification of dependable brain-based measures, such as those derived from electrophysiological techniques, would represent a key step toward better profiling of patients with major psychiatric disorders. A principled neurophysiological approach would also deepen our understanding of the physiopathology and inform therapeutic decisions. The present chapter focuses on a neurophysiological technique, based on the combination of neuronavigated Transcranial Magnetic Stimulation and Electroencephalography (TMS-EEG), which allows probing directly and non-invasively cortical excitability, plasticity as well as the fundamental oscillatory properties of thalamocortical circuits. Since these parameters are often altered in psychiatric disorders, neuronavigated TMS-EEG may be in a suitable position to provide neurophysiological objective measures to support the diagnosis of psychiatric disorders, to highlight their physiopathological underpinnings, and to objectively assess the efficacy of treatment options.
Psychiatry; Cerebral cortex; Rhythms; Biomarkers; Schizophrenia; Depression
Settore BIO/09 - Fisiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/759147
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