Neutropenia is defined by a decrease of the absolute neutrophil counts (ANCs) below the threshold of 1.8x109/L in the Caucasians and 1.5x109/L in people of African origins. This is valid from 1 year of age until adulthood, as the cut off for normality would be 1x109/L in newborns and children <1 year of age.1 Neutropenia is considered chronic if persists longer than 3 months, and is usually graded into mild (ANCs 1-1.5x109/L), moderate (ANCs 0.5-1 x109/L), and severe forms (ANCs<0.5 x109/L).1 The condition is further classified into congenital and acquired, and the latter in primary and secondary forms.2 Neutropenia cause is often obscure, particularly in adults, where idiopathic neutropenia is one of the most frequent reasons for hematologic referral. Moreover, the general practitioner and the hematologist himself can find it difficult to orientate among emerging clinical dilemmas: how much one should worry about moderate/mild forms? What tests to perform? Which is the priority for visits and workup? Once excluded oncologic and common secondary forms, how will I follow a patient with chronic idiopathic disease? Thereafter, we will focus on the available literature on acquired neutropenia of the adult and provide some practical advice for patient’ evaluation and follow up in the clinical practice.

A Review on Chronic Neutropenia of the Adult: Emerging Clinical Dilemmas / B. Fattizzo. - In: INTEGRATIVE CLINICAL AND PRACTICAL HEMATOLOGY. - ISSN 2688-397X. - 2:1(2019), pp. 12-20.

A Review on Chronic Neutropenia of the Adult: Emerging Clinical Dilemmas

B. Fattizzo
Primo
2019

Abstract

Neutropenia is defined by a decrease of the absolute neutrophil counts (ANCs) below the threshold of 1.8x109/L in the Caucasians and 1.5x109/L in people of African origins. This is valid from 1 year of age until adulthood, as the cut off for normality would be 1x109/L in newborns and children <1 year of age.1 Neutropenia is considered chronic if persists longer than 3 months, and is usually graded into mild (ANCs 1-1.5x109/L), moderate (ANCs 0.5-1 x109/L), and severe forms (ANCs<0.5 x109/L).1 The condition is further classified into congenital and acquired, and the latter in primary and secondary forms.2 Neutropenia cause is often obscure, particularly in adults, where idiopathic neutropenia is one of the most frequent reasons for hematologic referral. Moreover, the general practitioner and the hematologist himself can find it difficult to orientate among emerging clinical dilemmas: how much one should worry about moderate/mild forms? What tests to perform? Which is the priority for visits and workup? Once excluded oncologic and common secondary forms, how will I follow a patient with chronic idiopathic disease? Thereafter, we will focus on the available literature on acquired neutropenia of the adult and provide some practical advice for patient’ evaluation and follow up in the clinical practice.
Chronic idiopathic neutropenia; Autoimmune neutropenia; Myeloid neoplasms; Lymphoproliferative disorders
Settore MED/15 - Malattie del Sangue
2019
https://www.gratisoa.org/journals/index.php/ICPH/article/view/1532
Article (author)
File in questo prodotto:
File Dimensione Formato  
1532-Article Text-3966-1-10-20190409 (1).pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 639.63 kB
Formato Adobe PDF
639.63 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/758780
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact