The co-existence of both chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL) have been described in a few cases, either simultaneously or subsequently presenting. We report an unusual case of three hematological malignancies in the same patient: CLL, CML, and acute myeloid leukemia (AML). None of the three malignancies shared the same origin, since the marrow sample was negative for BCR-ABL1 transcript at the time of CLL diagnosis, CLL was in remission at CML diagnosis, and CML was in complete cytogenetic response at AML onset, indicating that this was not a blast crisis.Background: Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common proliferative disorders in Western countries, with an incidence of 4.2/100,000/year and 1-1.5/100,000/year, respectively [1-2]. The co-existence of both CML and CLL is an extremely rare event, even if it has been described in a few cases, either simultaneously or subsequently presenting . Above all, the presence of more than two different hematologic neoplasms has not been described in literature so far. In the present study we report a particular case of a CLL patient, who first developed CML and then acute myeloid leukemia (AML).
Three hematologic malignancies in the same patient : chronic lymphocytic leukemia, followed by chronic myeloid leukemia and acute myeloid leukemia / B. Fattizzo, T. Radice, D. Cattaneo, M. Pomati, W. Barcellini, A. Iurlo. - In: CLINICAL LABORATORY. - ISSN 1433-6510. - 60:11(2014), pp. 1929-1932.
|Titolo:||Three hematologic malignancies in the same patient : chronic lymphocytic leukemia, followed by chronic myeloid leukemia and acute myeloid leukemia|
FATTIZZO, BRUNO (Primo) (Corresponding)
|Parole Chiave:||Acute myeloid leukemia; Chronic lymphocytic leukemia; Chronic myeloid leukemia|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.7754/Clin.Lab.2014.140315|
|Appare nelle tipologie:||01 - Articolo su periodico|