Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulation within the tumor prevents phenotypic switching of the other cancer cells. Experiments reveal that hsa-mir-222 is a key factor enabling this process. Our results shed new light on melanoma plasticity, providing a potential target and guidance for therapeutic studies.

MicroRNA-222 Regulates Melanoma Plasticity / M.C. Lionetti, F. Cola, O. Chepizhko, M. Rita Fumagalli, F. Font Clos, R. Ravasio, S. Minucci, P. Canzano, M. Camera, G. Tiana, S. Zapperi, C.A.M. La Porta. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 9:8(2020 Aug 08), pp. 2573.1-2573.20. [10.3390/jcm9082573]

MicroRNA-222 Regulates Melanoma Plasticity

M.C. Lionetti
Primo
;
F. Cola
Secondo
;
F. FONT CLOS;R. Ravasio;S. Minucci;P. Canzano;M. Camera;G. Tiana;S. Zapperi
Penultimo
;
C.A.M. La Porta
Ultimo
2020

Abstract

Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem cell subpopulation within the tumor prevents phenotypic switching of the other cancer cells. Experiments reveal that hsa-mir-222 is a key factor enabling this process. Our results shed new light on melanoma plasticity, providing a potential target and guidance for therapeutic studies.
cancer stem cells; hsa-mir-222; kinetic equations; melanoma; phenotypic switching; reaction diffusion; tumor plasticity;
Settore MED/04 - Patologia Generale
Settore FIS/03 - Fisica della Materia
8-ago-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/757980
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