M r = 241.26, monoclinic, P21/c, a = 12.609 (6), b= 7.681 (4), c= 12.645 (6)A, /3= 94.97 (2) °, U= 1220.05 A 3, z=4, Dx= 1.31 gcm -3, 2(Mo K~) = 0.71069 A, /~ = 0.619 cm -~, F(000) = 476, room temperature, R = 0.064 for 1232 observed reflections. The product, a new synthetic molecule showing some activity as an inhibitor of the biosynthesis of ergosterol in fungi, shows a quaternary central C and the presence of two aromatic rings, one containing N (pyridine). These rings are inclined at an angle of 84 (1.1) ° to each other.
Structure of Ergosterol-Biosynthesis Inhibitors. I. Structure of l-(4-Fluorophenyl)- l-(3-pyddyl)-but-3-yn- 1-ol, C15Ha2FNO / A. Albinati, S.V. Meille, A. Arnoldi, R. Galli. - In: ACTA CRYSTALLOGRAPHICA. SECTION C, CRYSTAL STRUCTURE COMMUNICATIONS. - ISSN 0108-2701. - 41:(1985), pp. 97-99. [10.1107/s0108270185002906]
Structure of Ergosterol-Biosynthesis Inhibitors. I. Structure of l-(4-Fluorophenyl)- l-(3-pyddyl)-but-3-yn- 1-ol, C15Ha2FNO
A. Albinati;A. Arnoldi
;R. Galli
1985
Abstract
M r = 241.26, monoclinic, P21/c, a = 12.609 (6), b= 7.681 (4), c= 12.645 (6)A, /3= 94.97 (2) °, U= 1220.05 A 3, z=4, Dx= 1.31 gcm -3, 2(Mo K~) = 0.71069 A, /~ = 0.619 cm -~, F(000) = 476, room temperature, R = 0.064 for 1232 observed reflections. The product, a new synthetic molecule showing some activity as an inhibitor of the biosynthesis of ergosterol in fungi, shows a quaternary central C and the presence of two aromatic rings, one containing N (pyridine). These rings are inclined at an angle of 84 (1.1) ° to each other.
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