Precis: Our study demonstrated that in low-tension glaucoma patients, MP3- and HFA- derived retinal sensitivities were similar and strongly correlated, allowing the respective data to be interrelated. Purpose: To compare and correlate retinal sensitivities obtained by Nidek Microperimetry-3 (MP-3) with those obtained from the Humphrey Field Analyzer (HFA) in eyes with low-tension glaucoma (LTG). Methods: In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the two devices. Results: No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31▒dB; range 13.05-31.60 vs. HFA: 26.42±3.98▒dB; range 17.17-30.96), and a strong correlation (r=0.66, P < 0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP3 versus HFA-derived mean deviation (MD, r=0.57, P<0.001), as well as, the pattern standard deviation (PSD, r=0.67, P<0.001). The intraclass correlation coefficient was excellent (ICC=0.80, 95% CI 0.63 to 0.89), while the Bland-Altman analysis showed good agreement between the two devices with respect to retinal sensitivity. Conclusion: Retinal sensitivity measurements obtained by the MP-3 microperimetry instrument and the standard automated HFA perimeter were similar and highly correlated in patients with low tension glaucoma. Given the potential benefits of microperimetry technology such as auto-eye-tracking and potentially more precise structure-function correlations, the use of microperimetry to monitor visual function in glaucoma management warrants further consideration.
Comparison and Correlation of Retinal Sensitivity between Microperimetry and Standard Automated Perimetry in Low-Tension Glaucoma / T.C. Tepelus, S. Song, M.G. Nittala, M. Nassisi, S.R. Sadda, V. Chopra. - In: JOURNAL OF GLAUCOMA. - ISSN 1057-0829. - 29:10(2020 Oct), pp. 975-980. [10.1097/IJG.0000000000001599]
Comparison and Correlation of Retinal Sensitivity between Microperimetry and Standard Automated Perimetry in Low-Tension Glaucoma
M. Nassisi;
2020
Abstract
Precis: Our study demonstrated that in low-tension glaucoma patients, MP3- and HFA- derived retinal sensitivities were similar and strongly correlated, allowing the respective data to be interrelated. Purpose: To compare and correlate retinal sensitivities obtained by Nidek Microperimetry-3 (MP-3) with those obtained from the Humphrey Field Analyzer (HFA) in eyes with low-tension glaucoma (LTG). Methods: In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Global and pointwise retinal sensitivity measurements were compared and correlated between the two devices. Results: No statistically significant differences (P=0.85) were noted between the mean retinal sensitivities determined by each device (MP-3: 26.33±4.31▒dB; range 13.05-31.60 vs. HFA: 26.42±3.98▒dB; range 17.17-30.96), and a strong correlation (r=0.66, P < 0.001) was noted for retinal sensitivity measurements. In addition, moderate to strong correlations were observed between the mean retinal sensitivity derived by MP3 versus HFA-derived mean deviation (MD, r=0.57, P<0.001), as well as, the pattern standard deviation (PSD, r=0.67, P<0.001). The intraclass correlation coefficient was excellent (ICC=0.80, 95% CI 0.63 to 0.89), while the Bland-Altman analysis showed good agreement between the two devices with respect to retinal sensitivity. Conclusion: Retinal sensitivity measurements obtained by the MP-3 microperimetry instrument and the standard automated HFA perimeter were similar and highly correlated in patients with low tension glaucoma. Given the potential benefits of microperimetry technology such as auto-eye-tracking and potentially more precise structure-function correlations, the use of microperimetry to monitor visual function in glaucoma management warrants further consideration.
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