The metal-free preparation of diazoalkanes through the ringrearrangement of bicyclic triazolines is reported here. Their use in 1,3-dipolar cycloaddition reactions with electron-withdrawing alkenes wasinvestigated. This synthetic procedure allows differently substitutedpyrazolines to be obtained in few steps and with high atom economy.
Diastereoselective Synthesis of Pyrazolines by Metal-Free Rearrangement of Bicyclic Triazolines / R. Bucci, F. Clerici, S. Pellegrino, E. Erba. - In: SYNTHESIS. - ISSN 0039-7881. - 52:19(2020 Oct 16), pp. 2892-2898. [10.1055/s-0040-1707173]
Diastereoselective Synthesis of Pyrazolines by Metal-Free Rearrangement of Bicyclic Triazolines
R. BucciPrimo
;F. ClericiSecondo
;S. Pellegrino
Penultimo
;E. Erba
Ultimo
2020
Abstract
The metal-free preparation of diazoalkanes through the ringrearrangement of bicyclic triazolines is reported here. Their use in 1,3-dipolar cycloaddition reactions with electron-withdrawing alkenes wasinvestigated. This synthetic procedure allows differently substitutedpyrazolines to be obtained in few steps and with high atom economy.
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