The first synthesis of 1-aminoglucose analogue of the antitumor agent etoposide is accomplished by condensation of 4,6-tO-ethylidene-2,3-di-tO-trimethylsilyl-β-D-glucopyranosylamine with 4-bromo-4-deoxy-4′-demethylepipodophyllotoxin in the presence of Hg(CN)2.

The first synthesis of the N-glucosyl analogue of the antitumor agent etoposide / P. Allevi, M. Anastasia, P. Ciuffreda. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 34:45(1993), pp. 7313-7316.

The first synthesis of the N-glucosyl analogue of the antitumor agent etoposide

P. Allevi
Primo
;
M. Anastasia
Secondo
;
P. Ciuffreda
Ultimo
1993

Abstract

The first synthesis of 1-aminoglucose analogue of the antitumor agent etoposide is accomplished by condensation of 4,6-tO-ethylidene-2,3-di-tO-trimethylsilyl-β-D-glucopyranosylamine with 4-bromo-4-deoxy-4′-demethylepipodophyllotoxin in the presence of Hg(CN)2.
anticancer; antitumor; azaetoposide; etoposide; N-glycosilation
Settore BIO/10 - Biochimica
1993
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/749485
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