Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with still unknown etiology. We aimed at investigating the association between environmental and occupational factors with ALS risk. Methods: We performed a population-based case-control study in four Italian provinces (Catania, Modena, Novara, and Reggio Emilia) by administration of tailored questionnaires to ALS cases (n = 95) and randomly selected population referents (n = 135). We estimated ALS risk by calculating the odds ratio (OR) with its 95% confidence interval (CI) using an unconditional logistic regression model. Results: We found a positive association with disease risk for history of occupation in the agricultural sector (OR = 2.09, 95% CI 0.79–7.54), especially for longer than 10 years (OR = 2.72, 95% 1.02–7.20). Overall occupational exposure to solvents also suggested a positive association, especially for thinners (OR = 2.27, 95% CI 1.14–4.54) and paint removers (OR = 2.01, 95% CI 0.90–4.48). Both occupational and environmental exposure to electromagnetic fields show a slightly increased risk with OR = 1.69 (95% CI 0.70–4.09) and 2.41 (95% CI 1.13–5.12), respectively. Occupational but not environmental exposure to pesticides (OR = 1.22, 95% CI 0.63–2.37), particularly fungicides, and exposure to metals (OR = 4.20, 95% CI 1.88–9.38), particularly lead, mercury, and selenium, showed an imprecise but positive association.
Environmental and occupational risk factors of amyotrophic lateral sclerosis : a population-based case-control study / T. Filippini, M. Tesauro, M. Fiore, C. Malagoli, M. Consonni, F. Violi, L. Iacuzio, E. Arcolin, G.O. Conti, A. Cristaldi, P. Zuccarello, E. Zucchi, L. Mazzini, F. Pisano, I. Gagliardi, F. Patti, J. Mandrioli, M. Ferrante, M. Vinceti. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 17:8(2020 Apr), pp. 2882.1-2882.13.
|Titolo:||Environmental and occupational risk factors of amyotrophic lateral sclerosis : a population-based case-control study|
TESAURO, MARINA (Secondo)
|Parole Chiave:||Amyotrophic lateral sclerosis; Case-control study; Environmental factors; Occupational factors|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijerph17082882|
|Appare nelle tipologie:||01 - Articolo su periodico|