Background Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. Aim To test baclofen administration for the treatment of persistent hiccup. Method We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. Results Hiccup stopped in all patients after a single administration of the drug. Conclusions Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc. © 2013 John Wiley & Sons Ltd.

Baclofen in the treatment of persistent hiccup: A case series / A. Mirijello, G. Addolorato, C. D'Angelo, A. Ferrulli, G. Vassallo, M. Antonelli, L. Leggio, R. Landolfi. - In: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE. - ISSN 1368-5031. - 67:9(2013), pp. 918-921. [10.1111/ijcp.12184]

Baclofen in the treatment of persistent hiccup: A case series

Ferrulli A.;
2013

Abstract

Background Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. Aim To test baclofen administration for the treatment of persistent hiccup. Method We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. Results Hiccup stopped in all patients after a single administration of the drug. Conclusions Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc. © 2013 John Wiley & Sons Ltd.
Aged; Baclofen; Chronic Disease; Female; GABA-B Receptor Agonists; Hiccup; Humans; Male; Middle Aged; Muscle Relaxants, Central; Treatment Outcome; Young Adult
Settore MED/13 - Endocrinologia
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/744712
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