Objective: To explore the effect of physical exercise at high altitudes (HA) on male reproductive system. Design: Prospective study. Setting: Andrology Clinic, University of L'Aquila, Italy. Patient(s): Seven male mountaineers involved in an expedition at 5,900 m. Intervention(s): Semen analysis, sperm DNA fragmentation with flow cytometry, and reproductive hormone levels. Main Outcome Measure(s): Hormone levels were evaluated at sea level (SL) at baseline (SL-pre), after 22 days of exercise at HA (intermediate), and after 10 days upon reaching SL (SL-post). Sperm parameters, percentage of sperm with fragmented DNA, and body composition measures were evaluated at SL-pre and at SL-post. Result(s): A reduction of sperm concentration, of body mass index (BMI), of waist circumference, and of percentage of body fat was observed at SL-post compared with SL-pre values. Increased levels of FSH and PRL were observed at the intermediate point, and normalized at SL-post, whereas T was higher at SL-post compared with SL-pre levels. Conclusion(s): Physical exercise at HA is associated with a testicular dysfunction leading to a reduced sperm concentration probably through an altered spermiation. The improved body composition after physical exercise might explain the higher T levels observed after the expedition.

Physical Exercise at High Altitude Is Associated With a Testicular Dysfunction Leading to Reduced Sperm Concentration but Healthy Sperm Quality / F. Pelliccione, V. Verratti, A. D'Angeli, A. Micillo, C. Doria, A. Pezzella, G. Iacutone, F. Francavilla, C. Di Giulio, S. Francavilla. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 96:1(2011), pp. 28-33.

Physical Exercise at High Altitude Is Associated With a Testicular Dysfunction Leading to Reduced Sperm Concentration but Healthy Sperm Quality

C. Doria;
2011

Abstract

Objective: To explore the effect of physical exercise at high altitudes (HA) on male reproductive system. Design: Prospective study. Setting: Andrology Clinic, University of L'Aquila, Italy. Patient(s): Seven male mountaineers involved in an expedition at 5,900 m. Intervention(s): Semen analysis, sperm DNA fragmentation with flow cytometry, and reproductive hormone levels. Main Outcome Measure(s): Hormone levels were evaluated at sea level (SL) at baseline (SL-pre), after 22 days of exercise at HA (intermediate), and after 10 days upon reaching SL (SL-post). Sperm parameters, percentage of sperm with fragmented DNA, and body composition measures were evaluated at SL-pre and at SL-post. Result(s): A reduction of sperm concentration, of body mass index (BMI), of waist circumference, and of percentage of body fat was observed at SL-post compared with SL-pre values. Increased levels of FSH and PRL were observed at the intermediate point, and normalized at SL-post, whereas T was higher at SL-post compared with SL-pre levels. Conclusion(s): Physical exercise at HA is associated with a testicular dysfunction leading to a reduced sperm concentration probably through an altered spermiation. The improved body composition after physical exercise might explain the higher T levels observed after the expedition.
Sperm quality; sperm DNA fragmentation; male reproductive hormones; body composition; high altitude stress
Settore M-EDF/02 - Metodi e Didattiche delle Attivita' Sportive
Article (author)
File in questo prodotto:
File Dimensione Formato  
Physical exercise at high altitude.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 189.45 kB
Formato Adobe PDF
189.45 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/744118
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 27
social impact