Long-term exposure to high altitude causes adaptive changes in several blood biochemical markers along with a marked body mass reduction involving both the lean and fat components. The aim of this study was to evaluate the impact of extended physical strain, due to extensive trekking at high altitude, on body composition, selected biomarkers in the blood, and the protective role of a high-protein diet in muscle dysfunction. We found that physical strain at high altitude caused a significant reduction in body mass and body fat, with a concomitant increase in the cross-sectional area of thigh muscles and an unchanged total lean body mass. Further, we found reductions in plasma leptin and homocysteine, while myoglobin, insulin, and C-reactive protein significantly increased. Creatine kinase, lactate dehydrogenase, and leptin normalized per body fat were unchanged. These findings demonstrate that high-altitude hypoxia, involving extended physical effort, has an impact on muscle function and body composition, facilitating sarcopenia and affecting body mass and fat distribution. It also activates pro-inflammatory metabolic pathways in response to muscular distress. These changes can be mitigated by a provision of a high-protein diet.

Body Composition and Endocrine Adaptations To High Altitude Trekking in the Himalayas / G. Bosco, A. Paoli, A. Rizzato, G. Marcolin, M. Teresa Guagnano, C. Doria, S. Bhandari, T. Pietrangelo, V. Verratti (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Advancements and Innovations in Health Sciences / [a cura di] M. Pokorski. - [s.l] : Springer Nature Switzerland AG 2019, 2019. - ISBN 9783030327873. - pp. 61-68 [10.1007/5584_2019_414]

Body Composition and Endocrine Adaptations To High Altitude Trekking in the Himalayas

Christian Doria;
2019

Abstract

Long-term exposure to high altitude causes adaptive changes in several blood biochemical markers along with a marked body mass reduction involving both the lean and fat components. The aim of this study was to evaluate the impact of extended physical strain, due to extensive trekking at high altitude, on body composition, selected biomarkers in the blood, and the protective role of a high-protein diet in muscle dysfunction. We found that physical strain at high altitude caused a significant reduction in body mass and body fat, with a concomitant increase in the cross-sectional area of thigh muscles and an unchanged total lean body mass. Further, we found reductions in plasma leptin and homocysteine, while myoglobin, insulin, and C-reactive protein significantly increased. Creatine kinase, lactate dehydrogenase, and leptin normalized per body fat were unchanged. These findings demonstrate that high-altitude hypoxia, involving extended physical effort, has an impact on muscle function and body composition, facilitating sarcopenia and affecting body mass and fat distribution. It also activates pro-inflammatory metabolic pathways in response to muscular distress. These changes can be mitigated by a provision of a high-protein diet.
Adaptation; Blood biomarkers; Body composition; High altitude; Hypoxia; Inflammatory response; Trekking
Settore M-EDF/02 - Metodi e Didattiche delle Attivita' Sportive
Settore BIO/09 - Fisiologia
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
Bosco 2019 AEMB.pdf

non disponibili

Tipologia: Publisher's version/PDF
Dimensione 252.49 kB
Formato Adobe PDF
252.49 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/744104
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 8
social impact