Antibody-drug conjugates (ADCs) have been used for more than two decades as tools for the selective delivery of cytotoxic agents to the tumor site, with the aim to increase anti-cancer activity and spare normal tissues from undesired toxicity. Until recently, most ADC development activities have focused on the use of monoclonal antibodies, capable of selective binding and internalization into the target tumor cells. However, in principle, it would be conceivable to develop non-internalizing ADC products, which liberate their toxic payload in the extracellular environment. In this Chapter, we review previous work performed on non-internalizing ADC products, with a special emphasis on drug conjugates which selectively localize to the modified extracellular matrix in the neoplastic mass.

Antibody-Drug Conjugates: Targeting the Tumor Microenvironment / A. Dal Corso, S. Cazzamalli, D. Neri (CANCER DRUG DISCOVERY AND DEVELOPMENT). - In: Innovations for Next-Generation Antibody-Drug Conjugates / [a cura di] M. Damelin. - [s.l] : Humana press, 2018. - ISBN 9783319781532. - pp. 299-319

Antibody-Drug Conjugates: Targeting the Tumor Microenvironment

A. Dal Corso;
2018

Abstract

Antibody-drug conjugates (ADCs) have been used for more than two decades as tools for the selective delivery of cytotoxic agents to the tumor site, with the aim to increase anti-cancer activity and spare normal tissues from undesired toxicity. Until recently, most ADC development activities have focused on the use of monoclonal antibodies, capable of selective binding and internalization into the target tumor cells. However, in principle, it would be conceivable to develop non-internalizing ADC products, which liberate their toxic payload in the extracellular environment. In this Chapter, we review previous work performed on non-internalizing ADC products, with a special emphasis on drug conjugates which selectively localize to the modified extracellular matrix in the neoplastic mass.
Non-internalizing ADCs; Extracellular tumor antigens; Tumor microenvironment; Vascular targeting
Settore CHIM/06 - Chimica Organica
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/743533
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