Background and purpose: Although the main clinical features of COVID-19 infection are pulmonary, several associated neurological signs, symptoms and diseases are emerging. Incidence and characteristics of neurological complications are unclear. For this reason, the European Academy of Neurology (EAN) core COVID-19 Task Force initiated a survey on neurological symptoms observed in patients with COVID-19 infection. Methods: A 17-question on-line survey was made available on the EAN website and distributed to EAN members and other worldwide physicians starting on April 9th , 2020. Results: By April 27th, 2020, proper data were collected from 2,343 responders (out of 4,199), of whom 82.0% were neurologists, mostly from Europe. Most responders (74.7%) consulted patients with COVID-19 mainly in emergency rooms and in COVID-19 units. The majority (67.0%) had evaluated fewer than 10 patients with neurological manifestations of COVID-19 (neuro COVID-19). The most frequently reported neurological findings were headache (61.9%), myalgia (50.4%), anosmia (49.2%), ageusia (39.8%), impaired consciousness (29.3%), and psychomotor agitation (26.7%). Encephalopathy and acute cerebrovascular disorders were reported at 21.0%. Neurological manifestations were generally interpreted as being possibly related to COVID-19, they were most commonly recognized in patients with multiple general symptoms, and occurred at any time during infection. Conclusion: Neurologists are currently and actively involved in the management of neurological issues related to the COVID-19 pandemic. This survey justifies setting up a prospective registry to better capture the prevalence of patients with neuro COVID-19, neurological disease characteristics and the contribution of neurological manifestations to outcome.

The international EAN survey on neurological symptoms in patients with COVID-19 infection / E. Moro, A. Priori, E. Beghi, R. Helbok, L. Campiglio, C.L. Bassetti, E. Bianchi, L.F. Maia, S. Ozturk, F. Cavallieri, M. Zedde, J. Sellner, D. Bereczki, M. Rakusa, G. Di Liberto, A. Sauerbier, A. Pisani, A. Macerollo, R. Soffietti, P. Taba, M. Crean, A. Twardzik, C. Oreja-Guevara, B. Bodini, T.J. Jenkins, T.J. von Oertzen. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - (2020). [Epub ahead of print] [10.1111/ene.14407]

The international EAN survey on neurological symptoms in patients with COVID-19 infection

A. Priori
Secondo
;
L. Campiglio;G. Di Liberto;A. Macerollo;P. Taba;M. Crean;B. Bodini;
2020

Abstract

Background and purpose: Although the main clinical features of COVID-19 infection are pulmonary, several associated neurological signs, symptoms and diseases are emerging. Incidence and characteristics of neurological complications are unclear. For this reason, the European Academy of Neurology (EAN) core COVID-19 Task Force initiated a survey on neurological symptoms observed in patients with COVID-19 infection. Methods: A 17-question on-line survey was made available on the EAN website and distributed to EAN members and other worldwide physicians starting on April 9th , 2020. Results: By April 27th, 2020, proper data were collected from 2,343 responders (out of 4,199), of whom 82.0% were neurologists, mostly from Europe. Most responders (74.7%) consulted patients with COVID-19 mainly in emergency rooms and in COVID-19 units. The majority (67.0%) had evaluated fewer than 10 patients with neurological manifestations of COVID-19 (neuro COVID-19). The most frequently reported neurological findings were headache (61.9%), myalgia (50.4%), anosmia (49.2%), ageusia (39.8%), impaired consciousness (29.3%), and psychomotor agitation (26.7%). Encephalopathy and acute cerebrovascular disorders were reported at 21.0%. Neurological manifestations were generally interpreted as being possibly related to COVID-19, they were most commonly recognized in patients with multiple general symptoms, and occurred at any time during infection. Conclusion: Neurologists are currently and actively involved in the management of neurological issues related to the COVID-19 pandemic. This survey justifies setting up a prospective registry to better capture the prevalence of patients with neuro COVID-19, neurological disease characteristics and the contribution of neurological manifestations to outcome.
COVID-19; Coronarovirus; neurological; survey
Settore MED/26 - Neurologia
17-giu-2020
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/743529
Citazioni
  • ???jsp.display-item.citation.pmc??? 38
  • Scopus 67
  • ???jsp.display-item.citation.isi??? 62
social impact