This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on the different substrates identified as halogenated starting materials (activated substrates) or unactivated unsaturated systems, which then exploit Pd(0)- or Pd(II)- catalytic species. In particular, the use of the domino reactions, as intra- or intermolecular processes, are reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines. Different domino reaction typologies are the carboamination, aminoarylation, aminoacethoxylation, aminohalogenation, and aminoazidation.
Palladium-catalyzed benzodiazepines synthesis / M.S. Christodoulou, E.M. Beccalli, S. Giofre. - In: CATALYSTS. - ISSN 2073-4344. - 10:6(2020 Jun), pp. 634.1-634.38.
|Titolo:||Palladium-catalyzed benzodiazepines synthesis|
BECCALLI, EGLE MARIA (Corresponding)
|Parole Chiave:||Benzodiazepine; C-H activation; C-H functionalization; Cyclization; Domino process; Hartwig; Intramolecular Buchwald; N-arylation; Pd-catalysis|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||giu-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/catal10060634|
|Appare nelle tipologie:||01 - Articolo su periodico|