Collagenated heretologous cortico-cancelleus bone mix (CHCCBM) is largely employed in maxillary and dental surgery for regeneration procedures, and is similar to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial induces osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that CHCCBM enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1.

Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells / G. Beltramini, A. Russillo, C. Baserga, A. Pellati, A. Piva, V. Candotto. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 34:1 Suppl. 2(2020 Feb), pp. 1-5.

Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells

G. Beltramini
Primo
;
A. Russillo
Secondo
;
C. Baserga;V. Candotto
Ultimo
2020

Abstract

Collagenated heretologous cortico-cancelleus bone mix (CHCCBM) is largely employed in maxillary and dental surgery for regeneration procedures, and is similar to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial induces osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that CHCCBM enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1.
bone; dental pulp; gene expression; osteoblast differentiation; stem cells
Settore MED/29 - Chirurgia Maxillofacciale
Article (author)
File in questo prodotto:
File Dimensione Formato  
JBRHA34-1(s2).pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 559.99 kB
Formato Adobe PDF
559.99 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/741192
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact