In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization of surrogate markers because their association with survival has not been defined.
Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase / C.F. Murillo Perez, M.H. Harms, K.D. Lindor, H.R. van Buuren, G.M. Hirschfield, C. Corpechot, A.J. van der Meer, J.J. Feld, A. Gulamhusein, W.J. Lammers, C.Y. Ponsioen, M. Carbone, A.L. Mason, M.J. Mayo, P. Invernizzi, P.M. Battezzati, A. Floreani, A. Lleo, F. Nevens, K.V. Kowdley, T. Bruns, G.N. Dalekos, N.K. Gatselis, D. Thorburn, P.J. Trivedi, X. Verhelst, A. Parés, H.L.A. Janssen, B.E. Hansen. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - 115:7(2020 Jul), pp. 1066-1074. [10.14309/ajg.0000000000000557]
Goals of Treatment for Improved Survival in Primary Biliary Cholangitis: Treatment Target Should Be Bilirubin Within the Normal Range and Normalization of Alkaline Phosphatase
P.M. Battezzati;
2020
Abstract
In primary biliary cholangitis (PBC), bilirubin and alkaline phosphatase (ALP) are widely established as independent predictors of prognosis. Current treatment goals do not aim for normalization of surrogate markers because their association with survival has not been defined.
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